Higher viral load may explain the dominance of CRF02―AG in the molecular epidemiology of HIV in Ghana
Identifieur interne : 000F83 ( Main/Exploration ); précédent : 000F82; suivant : 000F84Higher viral load may explain the dominance of CRF02―AG in the molecular epidemiology of HIV in Ghana
Auteurs : Lucia Fischetti [Royaume-Uni] ; Ohene Opare-Sem [Ghana] ; Daniel Candotti [Royaume-Uni] ; Helen Lee [Royaume-Uni] ; Jean-Pierre Allain [Royaume-Uni]Source :
- AIDS : (London) [ 0269-9370 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- génétique : ARN complémentaire, ARN viral, Infections à VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- virologie : Infections à VIH.
- épidémiologie : Ghana, Infections à VIH.
- Pascal (Inist)
- Charge virale, Humains, Prévalence, SIDA, Réaction chaîne polymérase, Charge virale, Epidémiologie moléculaire, Ghana, Virus immunodéficience humaine, Virus HIV1, Arbre phylogénétique, Plasma sanguin, Asymptomatique, Donneur sang, Homme, Prévalence, RNA-directed DNA polymerase, Forme moléculaire, Pouvoir infectant, Reverse transcriptase.
- Wicri :
English descriptors
- KwdEn :
- AIDS, Asymptomatic, Blood donor, Blood plasma, Ghana, Ghana (epidemiology), HIV Infections (epidemiology), HIV Infections (genetics), HIV Infections (virology), HIV-1 (genetics), HIV-1 virus, Human, Human immunodeficiency virus, Humans, Infectivity, Molecular epidemiology, Molecular form, Phylogenetic tree, Polymerase chain reaction, Prevalence, RNA, Complementary (genetics), RNA, Viral (genetics), RNA-directed DNA polymerase, Viral Load, Viral load.
- MESH :
- chemical , genetics : RNA, Complementary, RNA, Viral.
- geographic , epidemiology : Ghana.
- epidemiology : HIV Infections.
- genetics : HIV Infections, HIV-1.
- virology : HIV Infections.
- Humans, Prevalence, Viral Load.
Abstract
Phylogenetic analysis of Ghanaian plasma samples from 84 asymptomatic candidate blood donors and 150 AIDS patients revealed a 63% prevalence of HIV-1 CRF02―AG. HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02―AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02―AG is compatible with higher infectivity and prevalence.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000105
- to stream PascalFrancis, to step Curation: 000040
- to stream PascalFrancis, to step Checkpoint: 000097
- to stream Main, to step Merge: 001033
- to stream PubMed, to step Corpus: 000215
- to stream PubMed, to step Curation: 000215
- to stream PubMed, to step Checkpoint: 000215
- to stream Ncbi, to step Merge: 000151
- to stream Ncbi, to step Curation: 000151
- to stream Ncbi, to step Checkpoint: 000151
- to stream Main, to step Merge: 000F71
- to stream Main, to step Curation: 000F83
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Higher viral load may explain the dominance of CRF02―AG in the molecular epidemiology of HIV in Ghana</title><author><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Komfo Anokye Teaching Hospital, Department of Medicine</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>2 aut.</sZ></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Blood Service, Cambridge Blood Centre</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0065331</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0065331 INIST</idno><idno type="RBID">Pascal:05-0065331</idno><idno type="wicri:Area/PascalFrancis/Corpus">000105</idno><idno type="wicri:Area/PascalFrancis/Curation">000040</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000097</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000097</idno><idno type="wicri:doubleKey">0269-9370:2004:Fischetti L:higher:viral:load</idno><idno type="wicri:Area/Main/Merge">001033</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15166539</idno><idno type="wicri:Area/PubMed/Corpus">000215</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000215</idno><idno type="wicri:Area/PubMed/Curation">000215</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000215</idno><idno type="wicri:Area/PubMed/Checkpoint">000215</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000215</idno><idno type="wicri:Area/Ncbi/Merge">000151</idno><idno type="wicri:Area/Ncbi/Curation">000151</idno><idno type="wicri:Area/Ncbi/Checkpoint">000151</idno><idno type="wicri:doubleKey">0269-9370:2004:Fischetti L:higher:viral:load</idno><idno type="wicri:Area/Main/Merge">000F71</idno><idno type="wicri:Area/Main/Curation">000F83</idno><idno type="wicri:Area/Main/Exploration">000F83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Higher viral load may explain the dominance of CRF02―AG in the molecular epidemiology of HIV in Ghana</title><author><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Komfo Anokye Teaching Hospital, Department of Medicine</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>2 aut.</sZ></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Blood Service, Cambridge Blood Centre</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></analytic><series><title level="j" type="main">AIDS : (London)</title><title level="j" type="abbreviated">AIDS : (Lond.)</title><idno type="ISSN">0269-9370</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">AIDS : (London)</title><title level="j" type="abbreviated">AIDS : (Lond.)</title><idno type="ISSN">0269-9370</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Asymptomatic</term><term>Blood donor</term><term>Blood plasma</term><term>Ghana</term><term>Ghana (epidemiology)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (genetics)</term><term>HIV Infections (virology)</term><term>HIV-1 (genetics)</term><term>HIV-1 virus</term><term>Human</term><term>Human immunodeficiency virus</term><term>Humans</term><term>Infectivity</term><term>Molecular epidemiology</term><term>Molecular form</term><term>Phylogenetic tree</term><term>Polymerase chain reaction</term><term>Prevalence</term><term>RNA, Complementary (genetics)</term><term>RNA, Viral (genetics)</term><term>RNA-directed DNA polymerase</term><term>Viral Load</term><term>Viral load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN complémentaire (génétique)</term><term>ARN viral (génétique)</term><term>Charge virale</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections à VIH (génétique)</term><term>Infections à VIH (virologie)</term><term>Infections à VIH (épidémiologie)</term><term>Prévalence</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Complementary</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV Infections</term><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN complémentaire</term><term>ARN viral</term><term>Infections à VIH</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Prevalence</term><term>Viral Load</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Charge virale</term><term>Humains</term><term>Prévalence</term><term>SIDA</term><term>Réaction chaîne polymérase</term><term>Charge virale</term><term>Epidémiologie moléculaire</term><term>Ghana</term><term>Virus immunodéficience humaine</term><term>Virus HIV1</term><term>Arbre phylogénétique</term><term>Plasma sanguin</term><term>Asymptomatique</term><term>Donneur sang</term><term>Homme</term><term>Prévalence</term><term>RNA-directed DNA polymerase</term><term>Forme moléculaire</term><term>Pouvoir infectant</term><term>Reverse transcriptase</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Phylogenetic analysis of Ghanaian plasma samples from 84 asymptomatic candidate blood donors and 150 AIDS patients revealed a 63% prevalence of HIV-1 CRF02―AG. HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02―AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02―AG is compatible with higher infectivity and prevalence.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name></region><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name></country><country name="Ghana"><noRegion><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaGhanaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:05-0065331
|texte= Higher viral load may explain the dominance of CRF02―AG in the molecular epidemiology of HIV in Ghana
}}
| This area was generated with Dilib version V0.6.31. |  |